Morphine interaction with prasugrel: a double-blind, cross-over trial in healthy volunteers.

ABSTRACT:

Background

Morphine decreases the concentrations and effects of clopidogrel, which could lead to treatment failure in myocardial infarction.

Objectives

To clarify whether more potent P2Y12-inhibitors may provide an effective alternative, we examined drug-drug interactions between morphine and prasugrel.

Methods

Twelve healthy volunteers received 60 mg prasugrel with placebo or 5 mg morphine intravenously in a randomized, double-blind, placebo-controlled, cross-over trial. Pharmacokinetics were determined by liquid chromatography tandem mass spectrometry, and prasugrel effects were measured by platelet function tests.

Results

Morphine neither diminished total drug exposure (AUC), which was the primary endpoint, nor significantly delayed drug absorption of prasug

SUBMITTER: Hobl EL 

PROVIDER: S-EPMC4805697 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature