Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC4232468 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Li Lingyin L Yin Qian Q Kuss Pia P Maliga Zoltan Z Millán José L JL Wu Hao H Mitchison Timothy J TJ
Nature chemical biology 20141026 12
Agonists of mouse STING (TMEM173) shrink and even cure solid tumors by activating innate immunity; human STING (hSTING) agonists are needed to test this therapeutic hypothesis in humans. The endogenous STING agonist is 2'3'-cGAMP, a second messenger that signals the presence of cytosolic double-stranded DNA. We report activity-guided partial purification and identification of ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP1) to be the dominant 2'3'-cGAMP hydrolyzing activity in cultured ...[more]