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Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility.

ABSTRACT: During spermiogenesis, histones are massively replaced with protamines. A previous report showed that Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile. Here, we have precisely deleted the Mst35B locus by homologous recombination, and we confirm the dispensability of Mst35Ba/b for fertility.

SUBMITTER: Tirmarche S

PROVIDER: S-EPMC4232549 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility.

Tirmarche Samantha S Kimura Shuhei S Sapey-Triomphe Laure L Sullivan William W Landmann Frédéric F Loppin Benjamin B

G3 (Bethesda, Md.) 20140917 11

During spermiogenesis, histones are massively replaced with protamines. A previous report showed that Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile. Here, we have precisely deleted the Mst35B locus by homologous recombination, and we confirm the dispensability of Mst35Ba/b for fertility. ...[more]

PMID: 25236732

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