Ontology highlight
ABSTRACT:
SUBMITTER: Grealish S
PROVIDER: S-EPMC4232736 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Grealish Shane S Diguet Elsa E Kirkeby Agnete A Mattsson Bengt B Heuer Andreas A Bramoulle Yann Y Van Camp Nadja N Perrier Anselme L AL Hantraye Philippe P Björklund Anders A Parmar Malin M
Cell stem cell 20141106 5
Considerable progress has been made in generating fully functional and transplantable dopamine neurons from human embryonic stem cells (hESCs). Before these cells can be used for cell replacement therapy in Parkinson's disease (PD), it is important to verify their functional properties and efficacy in animal models. Here we provide a comprehensive preclinical assessment of hESC-derived midbrain dopamine neurons in a rat model of PD. We show long-term survival and functionality using clinically r ...[more]