Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC4892985 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Chen Yuejun Y Xiong Man M Dong Yi Y Haberman Alexander A Cao Jingyuan J Liu Huisheng H Zhou Wenhao W Zhang Su-Chun SC
Cell stem cell 20160428 6
Transplantation of human pluripotent stem cell (hPSC)-derived neurons is a promising avenue for treating disorders including Parkinson's disease (PD). Precise control over engrafted cell activity is highly desired, as cells do not always integrate properly into host circuitry and can cause suboptimal graft function or undesired outcomes. Here, we show tunable rescue of motor function in a mouse model of PD, following transplantation of human midbrain dopaminergic (mDA) neurons differentiated fro ...[more]