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Blastopathies and microcephaly in a Chornobyl impacted region of Ukraine.

ABSTRACT: This population-based descriptive epidemiology study demonstrates that rates of conjoined twins, teratomas, neural tube defects, microcephaly, and microphthalmia in the Rivne province of Ukraine are among the highest in Europe. The province is 200 km distant from the Chornobyl site and its northern half, a region known as Polissia, is significantly polluted by ionizing radiation. The rates of neural tube defects, microcephaly and microphthalmia in Polissia are statistically significantly higher than in the rest of the province. A survey of at-birth head size showed that values were statistically smaller in males and females born in one Polissia county than among neonates born in the capital city. These observations provide clues for confirmatory and cause-effect prospective investigations. The strength of this study stems from a reliance on international standards prevalent in Europe and a decade-long population-based surveillance of congenital malformations in two distinct large populations. The limitations of this study, as those of other descriptive epidemiology investigations, is that identified cause-effect associations require further assessment by specific prospective investigations designed to address specific teratogenic factors.

SUBMITTER: Wertelecki W

PROVIDER: S-EPMC4233949 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Non-radiation risk factors for leukemia: A case-control study among chornobyl cleanup workers in Ukraine.

Project description:BACKGROUND:Occupational and environmental exposure to chemicals such as benzene has been linked to increased risk of leukemia. Cigarette smoking and alcohol consumption have also been found to affect leukemia risk. Previous analyses in a large cohort of Chornobyl clean-up workers in Ukraine found significant radiation-related increased risk for all leukemia types. We investigated the potential for additional effects of occupational and lifestyle factors on leukemia risk in this radiation-exposed cohort. METHODS:In a case-control study of chronic lymphocytic and other leukemias among Chornobyl cleanup workers, we collected data on a range of non-radiation exposures. We evaluated these and other potential risk factors in analyses adjusting for estimated bone marrow radiation dose. We calculated Odds Ratios and 95% Confidence Intervals in relation to lifestyle factors and occupational hazards. RESULTS:After adjusting for radiation, we found no clear association of leukemia risk with smoking or alcohol but identified a two-fold elevated risk for non-CLL leukemia with occupational exposure to petroleum (OR=2.28; 95% Confidence Interval 1.13, 6.79). Risks were particularly high for myeloid leukemias. No associations with risk factors other than radiation were found for chronic lymphocytic leukemia. CONCLUSIONS:These data - the first from a working population in Ukraine - add to evidence from several previous reports of excess leukemia morbidity in groups exposed environmentally or occupationally to petroleum or its products.

| S-EPMC4609257 | biostudies-literature

The Ukrainian-American study of leukemia and related disorders among Chornobyl cleanup workers from Ukraine: II. Estimation of bone marrow doses.

Project description:After the accident that took place on 26 April 1986 at the Chornobyl nuclear power plant, hundreds of thousands of cleanup workers were involved in emergency measures and decontamination activities. In the framework of an epidemiological study of leukemia and other related blood diseases among Ukrainian cleanup workers, individual bone marrow doses have been estimated for 572 cases and controls. Because dose records were available for only about half of the study subjects, a time-and-motion method of dose reconstruction that would be applicable to all study subjects, whether dead or alive, was developed. The doses were calculated in a stochastic mode, thus providing estimates of uncertainties. The arithmetic mean individual bone marrow doses were found to range from 0.00004 to 3,300 mGy, with an average value of 87 mGy over the 572 study subjects. The uncertainties, characterized by the geometric standard deviation of the probability distribution of the individual dose, varied from subject to subject and had a median value of about 2. These results should be treated as preliminary; it is likely that the dose calculations and particularly the uncertainty estimates will be improved in the follow-up of this effort.

| S-EPMC3033011 | biostudies-literature

Impact of uncertainties in exposure assessment on thyroid cancer risk among cleanup workers in Ukraine exposed due to the Chornobyl accident.

Project description:A large excess risk of thyroid cancer was observed among Belarusian/Russian/Baltic Chornobyl cleanup workers. A more recent study of Ukraine cleanup workers found more modest excess risks of thyroid cancer. Dose errors in this data are substantial, associated with model uncertainties and questionnaire response. Regression calibration is often used for dose-error adjustment, but may not adequately account for the full error distribution. We aimed to examine the impact of exposure-assessment uncertainties on thyroid cancer among Ukrainian cleanup workers using Monte Carlo maximum likelihood, and compare with results derived using regression calibration. Analyses assessed the sensitivity of results to various components of internal and external dose. Regression calibration yielded an excess odds ratio per Gy (EOR/Gy) of 0.437 (95% CI - 0.042, 1.577, p = 0.100), compared with the EOR/Gy using Monte Carlo maximum likelihood of 0.517 (95% CI - 0.039, 2.035, p = 0.093). Trend risk estimates for follicular morphology tumors exhibited much more extreme effects of full-likelihood adjustment, the EOR/Gy using regression calibration of 3.224 (95% CI - 0.082, 30.615, p = 0.068) becoming ~ 50% larger, 4.708 (95% CI - 0.075, 85.143, p = 0.066) when using Monte Carlo maximum likelihood. Results were sensitive to omission of external components of dose. In summary, use of Monte Carlo maximum likelihood adjustment for dose error led to increases in trend risks, particularly for follicular morphology thyroid cancers, where risks increased by ~ 50%, and were borderline significant. The unexpected finding for follicular tumors needs to be replicated in other exposed groups.

| S-EPMC10641599 | biostudies-literature

Latvia/Ukraine

Project description:Latvian and Ukrainian Mesolithic and Neolithic data

| PRJEB18067 | ENA

Sedimentary geology of the middle Carboniferous of the Donbas region (Dniepr-Donets Basin, Ukraine).

Project description:The Paleozoic Dniepr-Donets Basin in Belarus, Ukraine, and Russia forms a major hydrocarbon province. Although well- and seismic data have established a 20 km thick stratigraphy, field-studies of its sediments are scarce. The inverted Donbas segment (Ukraine) exposes the middle Carboniferous part of the basin's stratigraphy. Here, we provide detailed sedimentological data from 13 sections that cover 1.5 of the total of 5 km of the Bashkirian and Moscovian stages and assess the paleoenvironment and paleo-current directions. Middle Carboniferous deposition occurred in a shelf environment, with coal deposition, subordinate fluvial facies, and abundant lower and middle shoreface facies, comprising an intercalated package of potential source and reservoir rocks. Sedimentary facies indicate a paleodepth range from below storm wave base to near-coastal swamp environments. Sedimentation and subsidence were hence in pace, with subtle facies changes likely representing relative sea-level changes. Paleocurrent directions are remarkably consistently southeastward in time and space in the different sedimentary facies across the Donbas Fold Belt, illustrating a dominant sedimentary infill along the basin axis, with little basin margin influence. This suggests that the middle Carboniferous stratigraphy of the Dniepr-Donets basin to the northwest probably contains significant amounts of fluvial sandstones, important for assessing hydrocarbon reservoir potential.

| S-EPMC4367162 | biostudies-literature

Perceived Risk and Intentions to Practice Health Protective Behaviors in a Mining-Impacted Region.

Project description:Effective risk communication strategies are critical to reducing lead exposure in mining-impacted communities. Understanding the strength of the associations between perceived risk and individuals' behavioral intentions to protect their health is important for developing these strategies. We conducted a survey within three communities of northern Idaho, USA (n = 306) in or near a Superfund Megasite with legacy mining contamination. Survey data were used to test a theoretical model based on the Health Belief Model. Respondents had higher intentions to practice health protective behaviors when they perceived the risk of lead contamination as severe and recognized the benefits of practicing health protective behaviors. Women reported higher behavioral intentions than men, but age and mining affiliation were not significantly associated with behavioral intentions. Although managing lead hazards in communities impacted by mining is challenging due to widely distributed contamination, effective health risk messages, paired with remediation, are powerful tools to protect the health and safety of residents.

| S-EPMC7672644 | biostudies-literature

Samples Ukraine patients

Project description:Ukraine

| PRJEB58365 | ENA

Occurrence of Harmful Cyanobacteria in Drinking Water from a Severely Drought-Impacted Semi-arid Region.

Project description:Harmful cyanobacterial blooms have become increasingly common in freshwater ecosystems in recent decades, mainly due to eutrophication and climate change. Water becomes unreliable for human consumption. Here, we report a comprehensive study carried out to investigate the water quality of several Campina Grande reservoirs. Our approach included metagenomics, microbial abundance quantification, ELISA test for three cyanotoxins (microcystin, nodularins, and cylindrospermopsin), and in vivo ecotoxicological tests with zebrafish embryos. Cytometry analysis showed high cyanobacterial abundance, while metagenomics identified an average of 10.6% of cyanobacterial sequences, and demonstrated the presence of Microcystis, Cylindrospermopsis, and toxin coding genes in all ponds. Zebrafish embryos reared with pond water had high mortality and diverse malformations. Among the ponds analyzed, Araçagi showed the highest lethality (an average of 62.9 ± 0.8%), followed by Boqueirão (lethality average of 62.5 ± 0.8%). Here, we demonstrate that water from ponds undergoing extremely drought conditions have an abundance of potentially harmful cyanobacteria and their toxins. Our findings are consistent with a scenario in which polluted drinking water poses a great risk to human health.

| S-EPMC5835534 | biostudies-literature

Screening for the 137Cs body burden owing to the Chernobyl accident in Zhytomyr region, Ukraine: 2009-2018.

Project description:The Chernobyl Nuclear Power Plant accident released vast amounts of various fission products, of which 131I and 137Cs are considered the most important because they are a major source of radiation exposure to the general public. 137Cs, unlike 131I, has a 30-year half-life that continues to expose people internally and externally for several decades after being deposited into the ground. 137Cs can be easily transmitted to the body through the intake of products and wild forest foodstuffs produced in contaminated areas. In the early phase, external exposure to 137Cs was predominant; however, it gradually diminished, mostly owing to horizontal and vertical distribution, and internal exposure started gaining dominance. Prior studies have shown that people in the affected areas have been constantly subjected to the inevitable low-grade internal exposure, which in turn has led to high anxiety and concern regarding the potential health effects. The present 10-year study assessed the latest status of the body burden among residents of the contaminated parts of the Zhytomyr region of Ukraine by measuring the internal concentration of 137Cs using the whole-body counter installed at the Medical Center of Korosten city. Almost 110 000 examinees from eight different districts were screened between 2009 and 2018. The study area was situated to the west of Chernobyl, which experienced a significant fallout of 137Cs and 131I from the Chernobyl Nuclear Power Plant. We analyzed the data for internal exposure to 137Cs by obtaining the actual magnitude, pace, and pattern of change for each year. During the study, the average 137Cs concentration in residents fell from 21.6 Bq/kg at the beginning of the study to 3.0 Bq/kg at the end of the study. The proportion of examinees with detectable levels had also fallen rapidly, from 45% to 11%. We found a weaker seasonal effect and a significantly higher Bq/kg concentration in adolescents than in other age groups.

| S-EPMC7810316 | biostudies-literature

Genome diversity in Ukraine.

Project description:BackgroundThe main goal of this collaborative effort is to provide genome-wide data for the previously underrepresented population in Eastern Europe, and to provide cross-validation of the data from genome sequences and genotypes of the same individuals acquired by different technologies. We collected 97 genome-grade DNA samples from consented individuals representing major regions of Ukraine that were consented for public data release. BGISEQ-500 sequence data and genotypes by an Illumina GWAS chip were cross-validated on multiple samples and additionally referenced to 1 sample that has been resequenced by Illumina NovaSeq6000 S4 at high coverage.ResultsThe genome data have been searched for genomic variation represented in this population, and a number of variants have been reported: large structural variants, indels, copy number variations, single-nucletide polymorphisms, and microsatellites. To our knowledge, this study provides the largest to-date survey of genetic variation in Ukraine, creating a public reference resource aiming to provide data for medical research in a large understudied population.ConclusionsOur results indicate that the genetic diversity of the Ukrainian population is uniquely shaped by evolutionary and demographic forces and cannot be ignored in future genetic and biomedical studies. These data will contribute a wealth of new information bringing forth a wealth of novel, endemic and medically related alleles.

| S-EPMC7804371 | biostudies-literature

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