Dataset Information

Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the Austrian Stroke Prevention Study.

ABSTRACT:

Objectives

To examine the association between plasma concentrations of antioxidative micronutrients and leukocyte telomere length (LTL) in elderly adults.

Design

Cross-sectional cohort study.

Setting

Austrian Stroke Prevention Study, a population-based cohort study on brain aging.

Participants

Individuals with a mean age of 66 ± 7 (n = 786; 58% female).

Measurements

Concentrations of vitamin C, lutein, zeaxanthin, ?-cryptoxanthin, canthaxanthin, lycopene, ?- and ?-tocopherol, ?- and ?-carotene, and retinol in plasma, advanced oxidation protein products as a measure of oxidative stress in serum, and LTL were measured. Vitamins and carotenoids were measured using high-performance liquid chromatography, advanced oxidation protein products using spectrophotometry, and telomere length using quantitative real-time polymerase chain reaction.

Results

Multiple linear regression analyses with adjustment for age and sex demonstrated that higher lutein, zeaxanthin, and vitamin C concentrations were strongly associated with longer telomere length. The associations were independent of body mass index, maximum oxygen uptake, and vascular risk factors and were not mediated by advanced oxidation protein products content.

Conclusion

This study provides first evidence that higher lutein, zeaxanthin, and vitamin C concentrations in plasma are associated with longer LTL in normal elderly persons and suggest a protective role of these vitamins in telomere maintenance.

SUBMITTER: Sen A

PROVIDER: S-EPMC4234001 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the Austrian Stroke Prevention Study.

Sen Abhijit A Marsche Gunther G Freudenberger Paul P Schallert Michael M Toeglhofer Anna M AM Nagl Christoph C Schmidt Reinhold R Launer Lenore J LJ Schmidt Helena H

Journal of the American Geriatrics Society 20140115 2

<h4>Objectives</h4>To examine the association between plasma concentrations of antioxidative micronutrients and leukocyte telomere length (LTL) in elderly adults.<h4>Design</h4>Cross-sectional cohort study.<h4>Setting</h4>Austrian Stroke Prevention Study, a population-based cohort study on brain aging.<h4>Participants</h4>Individuals with a mean age of 66 ± 7 (n = 786; 58% female).<h4>Measurements</h4>Concentrations of vitamin C, lutein, zeaxanthin, β-cryptoxanthin, canthaxanthin, lycopene, α- a ...[more]

PMID: 24428184

Similar Datasets

Project description:There are controversial results if leukocyte telomere length (LTL) is related to structural brain changes and cognitive decline in aging. Here, we investigated the association between LTL and 1) global MRI correlates of brain aging such as brain parenchymal fraction (BPF) and white matter hyperintensities (WMH) load and Fazekas score as well as 2) global (g-factor) and domain-specific cognition such as attention/speed, conceptualization, memory, and visuopractical skills. In total, 909 participants of the Austrian Stroke Prevention Study with LTL, MRI, and cognitive tests were included. There were 388 (42.7%) men, and the mean age was 65.9 years. Longer LTL was significantly associated with larger BPF (? = 0.43, p < 0.001), larger WMH load (? = 0.03, p = 0.04), and score (? = 0.05, p = 0.04) after adjusting for age, sex, vascular risk factors, and ApoE4 carrier status. The effect on BPF was more significant in the subgroups of women (? = 0.51, p = 0.001), age >65 years (? = 0.58, p = 0.002), BMI ? 25 (? = 0.40, p = 0.004), education ?10 years (? = 0.42, p = 0.002), hypertensives (? = 0.51, p = 0.001), cardiovascular disease (CVD) (? = 0.58, p = 0.005), non-diabetics (? = 0.42, p < 0.001), and Apoe4 non-carriers (? = 0.49, p < 0.001). The effect on WMH was significant within the hypertensives (load: ? = 0.04, p = 0.02), non-diabetics (load:? = 0.03, p = 0.01; score: ? = 0.06, p = 0.02), in those with education ?10 years (load: ? = 0.03, p = 0.04; score: ? = 0.07, p = 0.02), in ApoE4 non-carriers (load: ? = 0.03, p = 0.02; score: ? = 0.07, p = 0.01) and in subjects without CVD (score: ? = 0.06, p = 0.05). We only observed a significant association between LTL and the cognitive domain of attention/speed, which was confined to the subgroups of BMI ? 25 (? = 0.04, p = 0.05) and education ?10 years (? = 0.04, p = 0.05). The effect of LTL on attention/speed was partly mediated in both subgroups by BPF (? = 0.02, 95% CI = 0.01:0.03) when tested by bootstrapping. Our results support a strong protective role of longer LTL on global brain volume which in turn may contribute to better cognitive functions, especially in the attention/speed domain in the elderly.

Dataset Information

Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the Austrian Stroke Prevention Study.

Objectives

Design

Setting

Participants

Measurements

Results

Conclusion

Publications

Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the Austrian Stroke Prevention Study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure