Ontology highlight
ABSTRACT:
SUBMITTER: Power RA
PROVIDER: S-EPMC4234115 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Power Robert A RA Keller Matthew C MC Ripke Stephan S Abdellaoui Abdel A Wray Naomi R NR Sullivan Patrick F PF Breen Gerome G
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20140130 2
Genome-wide association studies (GWASs) of major depressive disorder (MDD) have yet to identify variants that surpass the threshold for genome-wide significance. A recent study reported that runs of homozygosity (ROH) are associated with schizophrenia, reflecting a novel genetic risk factor resulting from increased parental relatedness and recessive genetic effects. Here, we explore the possibility of such a recessive model in MDD. In a sample of 9,238 cases and 9,521 controls reported in a rece ...[more]