Ontology highlight
ABSTRACT:
SUBMITTER: Pattabiraman DR
PROVIDER: S-EPMC4234172 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Pattabiraman Diwakar R DR Weinberg Robert A RA
Nature reviews. Drug discovery 20140701 7
Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive study. Their properties and mechanisms of formation have become a major focus of current cancer research, in part because of their enhanced ability to initiate and drive tumour growth and their intrinsic resistance to conventional therapeutics. The discovery that activation of the epithelial-to-mesenchymal transition (EMT) programme in carcinoma cells can give rise to cells with stem-like properties has p ...[more]