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Complex reconfiguration of DNA nanostructures.

ABSTRACT: Nucleic acids have been used to create diverse synthetic structural and dynamic systems. Toehold-mediated strand displacement has enabled the construction of sophisticated circuits, motors, and molecular computers. Yet it remains challenging to demonstrate complex structural reconfiguration in which a structure changes from a starting shape to another arbitrarily prescribed shape. To address this challenge, we have developed a general structural-reconfiguration method that utilizes the modularly interconnected architecture of single-stranded DNA tile and brick structures. The removal of one component strand reveals a newly exposed toehold on a neighboring strand, thus enabling us to remove regions of connected component strands without the need to modify the strands with predesigned external toeholds. By using this method, we reconfigured a two-dimensional rectangular DNA canvas into diverse prescribed shapes. We also used this method to reconfigure a three-dimensional DNA cuboid.

SUBMITTER: Wei B

PROVIDER: S-EPMC4235524 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Complex reconfiguration of DNA nanostructures.

Wei Bryan B Ong Luvena L LL Chen Jeffrey J Jaffe Alexander S AS Yin Peng P

Angewandte Chemie (International ed. in English) 20140604 29

Nucleic acids have been used to create diverse synthetic structural and dynamic systems. Toehold-mediated strand displacement has enabled the construction of sophisticated circuits, motors, and molecular computers. Yet it remains challenging to demonstrate complex structural reconfiguration in which a structure changes from a starting shape to another arbitrarily prescribed shape. To address this challenge, we have developed a general structural-reconfiguration method that utilizes the modularly ...[more]

PMID: 24899518

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