Ontology highlight
ABSTRACT:
SUBMITTER: Shi J
PROVIDER: S-EPMC4236231 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Shi Junwei J Vakoc Christopher R CR
Molecular cell 20140601 5
The bromodomain and extraterminal (BET) protein Brd4 recruits transcriptional regulatory complexes to acetylated chromatin. While Brd4 is considered to be a general transcriptional regulator, pharmacological inhibition of BET proteins shows therapeutic activity in a variety of different pathologies, particularly in models of cancer and inflammation. Such effects have been attributed to a specific set of downstream target genes whose expression is disproportionately sensitive to pharmacological t ...[more]