Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC4729770 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Zhang Zhenfeng Z Ma Pengfei P Jing Ying Y Yan Ying Y Cai Mei-Chun MC Zhang Meiying M Zhang Shengzhe S Peng Huixin H Ji Zhi-Liang ZL Di Wen W Gu Zhenyu Z Gao Wei-Qiang WQ Zhuang Guanglei G
Theranostics 20160101 2
Ovarian cancer is responsible for the highest mortality among all gynecologic malignancies, and novel therapies are urgently needed to improve patient outcome. Here we performed an integrative genomic analysis and identified the bromodomain and extraterminal domain (BET) protein BRD4 as a potential therapeutic target in ovarian cancer. Suppression of BRD4 using small-molecule BET inhibitors JQ1 and I-BET151, or dual kinase-bromodomain inhibitor volasertib, led to robust and broad antitumor effec ...[more]