Ontology highlight
ABSTRACT:
SUBMITTER: van Beugen BJ
PROVIDER: S-EPMC4236409 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
van Beugen Boeke J BJ Qiao Xin X Simmons Dana H DH De Zeeuw Chris I CI Hansel Christian C
Learning & memory (Cold Spring Harbor, N.Y.) 20141117 12
Ampakines are allosteric modulators of AMPA receptors that facilitate hippocampal long-term potentiation (LTP) and learning, and have been considered for the treatment of cognition and memory deficits. Here, we show that the ampakine CX546 raises the amplitude and slows the decay time of excitatory postsynaptic currents (EPSCs) at cerebellar parallel fiber (PF) to Purkinje cell synapses, thus resembling CX546 effects described at hippocampal synapses. Using the fluorescent calcium indicator dye ...[more]