Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit.
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ABSTRACT:
SUBMITTER: Diaz-Alonso J
PROVIDER: S-EPMC7500950 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit.
Díaz-Alonso Javier J Morishita Wade W Incontro Salvatore S Simms Jeffrey J Holtzman Julia J Gill Michael M Mucke Lennart L Malenka Robert C RC Nicoll Roger A RA
eLife 20200824
We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs. ...[more]
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