Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit.

ABSTRACT: We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.

SUBMITTER: Diaz-Alonso J 

PROVIDER: S-EPMC7500950 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature