Ontology highlight
ABSTRACT:
SUBMITTER: Rynda-Apple A
PROVIDER: S-EPMC4237004 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Rynda-Apple Agnieszka A Harmsen Ann A Erickson Anfin S AS Larson Kyle K Morton Rachelle V RV Richert Laura E LE Harmsen Allen G AG
European journal of immunology 20140901 11
Superinfection in mice at day 7 postinfluenza infection exacerbates bacterial pneumonia at least in part via downstream effects of increased IFN-γ signaling. Here we show that up to 3 days postinfluenza infection, mice have reduced susceptibility to superinfection with methicillin-resistant Staphylococcus aureus (MRSA), but that superinfection during that time exacerbated influenza disease. This was due to IL-13 signaling that was advantageous for resolving MRSA infection via inhibition of IFN-γ ...[more]