Ontology highlight
ABSTRACT:
SUBMITTER: Wu M
PROVIDER: S-EPMC5538876 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Wu Muzo M Gibbons John G JG DeLoid Glen M GM Bedugnis Alice S AS Thimmulappa Rajesh K RK Biswal Shyam S Kobzik Lester L
American journal of physiology. Lung cellular and molecular physiology 20170413 1
Downregulation of the alveolar macrophage (AM) receptor with collagenous structure (MARCO) leads to susceptibility to postinfluenza bacterial pneumonia, a major cause of morbidity and mortality. We sought to determine whether immunomodulation of MARCO could improve host defense and resistance to secondary bacterial pneumonia. RNAseq analysis identified a striking increase in MARCO expression between <i>days 9</i> and <i>11</i> after influenza infection and indicated important roles for Akt and N ...[more]