Promoter methylation analysis of WNT/?-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer.
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ABSTRACT:
SUBMITTER: Samaei NM
PROVIDER: S-EPMC4237828 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer.
Samaei Nader Mansour NM Yazdani Yaghoub Y Alizadeh-Navaei Reza R Azadeh Hossein H Farazmandfar Touraj T
Journal of biomedical science 20140809
<h4>Background</h4>Aberrant DNA methylation as the most important reason making epigenetic silencing of genes is a main mechanism of gene inactivation in patients with colorectal cancer. In this study, we decided to identify promoter methylation status of ten genes encoding WNT negative regulators, and measure the expression of DNMT1 enzyme in colorectal cancer samples.<h4>Results</h4>Aberrant methylation of APC gene was statistically significant associated with age over 50 (p = 0.017), DDK3 wit ...[more]
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