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CREPT facilitates colorectal cancer growth through inducing Wnt/?-catenin pathway by enhancing p300-mediated ?-catenin acetylation.


ABSTRACT: Using whole genome sequencing, we identified gene amplification of CREPT in colorectal cancer (CRC). In this study, we aim to clarify its clinical significance, biological effects, and mechanism in CRC. CREPT was upregulated in CRC cell lines and in 47.37% (72/152) of primary CRC tumors. Amplification of CREPT was detected in 48.28% (56/116) of primary CRC tumors, which was positively correlated with its overexpression (P?

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6021369 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation.

Zhang Yanquan Y   Wang Shiyan S   Kang Wei W   Liu Chunxiao C   Dong Yujuan Y   Ren Fangli F   Wang Yinyin Y   Zhang Jinglin J   Wang Guoping G   To Ka Fai KF   Zhang Xueji X   Sung Joseph Jy JJ   Chang Zhijie Z   Yu Jun J  

Oncogene 20180322 26


Using whole genome sequencing, we identified gene amplification of CREPT in colorectal cancer (CRC). In this study, we aim to clarify its clinical significance, biological effects, and mechanism in CRC. CREPT was upregulated in CRC cell lines and in 47.37% (72/152) of primary CRC tumors. Amplification of CREPT was detected in 48.28% (56/116) of primary CRC tumors, which was positively correlated with its overexpression (P < 0.001). Multivariate analysis showed that CRC patients with CREPT protei  ...[more]

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