Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6021369 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Zhang Yanquan Y Wang Shiyan S Kang Wei W Liu Chunxiao C Dong Yujuan Y Ren Fangli F Wang Yinyin Y Zhang Jinglin J Wang Guoping G To Ka Fai KF Zhang Xueji X Sung Joseph Jy JJ Chang Zhijie Z Yu Jun J
Oncogene 20180322 26
Using whole genome sequencing, we identified gene amplification of CREPT in colorectal cancer (CRC). In this study, we aim to clarify its clinical significance, biological effects, and mechanism in CRC. CREPT was upregulated in CRC cell lines and in 47.37% (72/152) of primary CRC tumors. Amplification of CREPT was detected in 48.28% (56/116) of primary CRC tumors, which was positively correlated with its overexpression (P < 0.001). Multivariate analysis showed that CRC patients with CREPT protei ...[more]