Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases.
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ABSTRACT:
SUBMITTER: Gstir R
PROVIDER: S-EPMC4238357 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
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Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases.
Gstir Ronald R Schafferer Simon S Scheideler Marcel M Misslinger Matthias M Griehl Matthias M Daschil Nina N Humpel Christian C Obermair Gerald J GJ Schmuckermair Claudia C Striessnig Joerg J Flucher Bernhard E BE Hüttenhofer Alexander A
RNA (New York, N.Y.) 20141024 12
We have generated a novel, neuro-specific ncRNA microarray, covering 1472 ncRNA species, to investigate their expression in different mouse models for central nervous system diseases. Thereby, we analyzed ncRNA expression in two mouse models with impaired calcium channel activity, implicated in Epilepsy or Parkinson's disease, respectively, as well as in a mouse model mimicking pathophysiological aspects of Alzheimer's disease. We identified well over a hundred differentially expressed ncRNAs, e ...[more]
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