Ontology highlight
ABSTRACT:
SUBMITTER: Lou Q
PROVIDER: S-EPMC4239057 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20141120 11
OCILRP2 is a typical Type-II transmembrane protein that is selectively expressed in activated T lymphocytes, dendritic cells, and B cells and functions as a novel co-stimulator of T cell activation. However, the signaling pathways underlying OCILRP2 in T cell activation are still not completely understood. In this study, we found that the knockdown of OCILRP2 expression with shRNA or the blockage of its activity by an anti-OCILRP2 antagonist antibody reduced CD3/CD28-costimulated EL4 T cell viab ...[more]