Ontology highlight
ABSTRACT:
SUBMITTER: Jacque E
PROVIDER: S-EPMC4451135 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Jacque Emilie E Schweighoffer Edina E Tybulewicz Victor L J VL Ley Steven C SC
The Journal of experimental medicine 20150518 6
B cell activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic survival of mature B cells. Earlier in vitro experiments with inhibitors that block MEK 1 and 2 suggested that activation of ERK 1 and 2 MAP kinases is required for BAFF-R to promote B cell survival. However, these inhibitors are now known to also inhibit MEK5, which activates the related MAP kinase ERK5. In the present study, we demonstrated that BAFF-induced B cell survival was actually i ...[more]