High-fat diet-induced changes in liver thioredoxin and thioredoxin reductase as a novel feature of insulin resistance.
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ABSTRACT:
SUBMITTER: Qin H
PROVIDER: S-EPMC4239481 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
High-fat diet-induced changes in liver thioredoxin and thioredoxin reductase as a novel feature of insulin resistance.
Qin Huijun H Zhang Xiaolin X Ye Fei F Zhong Liangwei L
FEBS open bio 20141031
High-fat diet (HFD) can induce oxidative stress. Thioredoxin (Trx) and thioredoxin reductase (TrxR) are critical antioxidant proteins but how they are affected by HFD remains unclear. Using HFD-induced insulin-resistant mouse model, we show here that liver Trx and TrxR are significantly decreased, but, remarkably, the degree of their S-acylation is increased after consuming HFD. These HFD-induced changes in Trx/TrxR may reflect abnormalities of lipid metabolism and insulin signaling transduction ...[more]
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