Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC4241451 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Biophysical journal 20141101 10
Erythropoietin receptor (EpoR) dimerization is an important step in erythrocyte formation. Its transmembrane domain (TMD) and juxtamembrane (JM) region are essential for signal transduction across the membrane. A construct compassing residues S212-P259 and containing the TMD and JM region of the human EpoR was purified and reconstituted in detergent micelles. The solution structure of the construct was determined in dodecylphosphocholine (DPC) micelles by solution NMR spectroscopy. Structural an ...[more]