Ontology highlight
ABSTRACT:
SUBMITTER: Afrin LB
PROVIDER: S-EPMC4242119 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
The American journal of the medical sciences 20141201 6
Some sickle cell anemia (SCA) patients suffer significantly worse phenotypes than others. Causes of such disparities are incompletely understood. Comorbid chronic inflammation likely is a factor. Recently, mast cell (MC) activation (creating an inflammatory state) was found to be a significant factor in sickle pathobiology and pain in a murine SCA model. Also, a new realm of relatively noncytoproliferative MC disease termed MC activation syndrome (MCAS) has been identified recently. MCAS has not ...[more]