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Idiopathic Mast Cell Activation Syndrome With Associated Salicylate Intolerance.

ABSTRACT: Idiopathic mast cell activation syndrome can be a rare cause for chronic abdominal pain in children. It remains a diagnosis by exclusion that can be particularly challenging due to the vast variety of possible clinical manifestations. We present a 13-year-old boy who suffered from a multitude of unspecific complaints over a long period of time. In this case, an assessment of mast cell-derived metabolites and immunohistochemical analysis of bioptic specimen was worthwhile. After ruling out, primary (oncologic) and secondary causes for mast cell activation, pharmacologic treatment adapted to the patient's salicylate intolerance resulted in a major relief of symptoms.

SUBMITTER: Rechenauer T

PROVIDER: S-EPMC5881244 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Idiopathic Mast Cell Activation Syndrome With Associated Salicylate Intolerance.

Rechenauer Tobias T Raithel Martin M Götze Thomas T Siebenlist Gregor G Rückel Aline A Baenkler Hanns-Wolf HW Hartmann Arndt A Haller Florian F Hoerning André A

Frontiers in pediatrics 20180327

Idiopathic mast cell activation syndrome can be a rare cause for chronic abdominal pain in children. It remains a diagnosis by exclusion that can be particularly challenging due to the vast variety of possible clinical manifestations. We present a 13-year-old boy who suffered from a multitude of unspecific complaints over a long period of time. In this case, an assessment of mast cell-derived metabolites and immunohistochemical analysis of bioptic specimen was worthwhile. After ruling out, prima ...[more]

PMID: 29637062

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