Ontology highlight
ABSTRACT:
SUBMITTER: Saeed S
PROVIDER: S-EPMC4242194 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20140901 6204
Monocyte differentiation into macrophages represents a cornerstone process for host defense. Concomitantly, immunological imprinting of either tolerance or trained immunity determines the functional fate of macrophages and susceptibility to secondary infections. We characterized the transcriptomes and epigenomes in four primary cell types: monocytes and in vitro-differentiated naïve, tolerized, and trained macrophages. Inflammatory and metabolic pathways were modulated in macrophages, including ...[more]