Ontology highlight
ABSTRACT:
SUBMITTER: Wallner S
PROVIDER: S-EPMC4967341 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Epigenetics & chromatin 20160729
<h4>Background</h4>Monocyte-to-macrophage differentiation involves major biochemical and structural changes. In order to elucidate the role of gene regulatory changes during this process, we used high-throughput sequencing to analyze the complete transcriptome and epigenome of human monocytes that were differentiated in vitro by addition of colony-stimulating factor 1 in serum-free medium.<h4>Results</h4>Numerous mRNAs and miRNAs were significantly up- or down-regulated. More than 100 discrete D ...[more]