Ontology highlight
ABSTRACT:
SUBMITTER: Haan JC
PROVIDER: S-EPMC4243240 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Haan Josien C JC Labots Mariette M Rausch Christian C Koopman Miriam M Tol Jolien J Mekenkamp Leonie J M LJ van de Wiel Mark A MA Israeli Danielle D van Essen Hendrik F HF van Grieken Nicole C T NC Voorham Quirinus J M QJ Bosch Linda J W LJ Qu Xueping X Kabbarah Omar O Verheul Henk M W HM Nagtegaal Iris D ID Punt Cornelis J A CJ Ylstra Bauke B Meijer Gerrit A GA
Nature communications 20141114
Response to drug therapy in individual colorectal cancer (CRC) patients is associated with tumour biology. Here we describe the genomic landscape of tumour samples of a homogeneous well-annotated series of patients with metastatic CRC (mCRC) of two phase III clinical trials, CAIRO and CAIRO2. DNA copy number aberrations of 349 patients are determined. Within three treatment arms, 194 chromosomal subregions are associated with progression-free survival (PFS; uncorrected single-test P-values <0.00 ...[more]