Ontology highlight
ABSTRACT:
SUBMITTER: Yaeger R
PROVIDER: S-EPMC5765991 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Cancer cell 20180101 1
Metastatic colorectal cancers (mCRCs) are clinically heterogeneous, but the genomic basis of this variability remains poorly understood. We performed prospective targeted sequencing of 1,134 CRCs. We identified splice alterations in intronic regions of APC and large in-frame deletions in CTNNB1, increasing oncogenic WNT pathway alterations to 96% of CRCs. Right-sided primary site in microsatellite stable mCRC was associated with shorter survival, older age at diagnosis, increased mutations, and ...[more]