Ontology highlight
ABSTRACT:
SUBMITTER: Andersson EK
PROVIDER: S-EPMC4243843 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Andersson Emma K EK Bengtsson Christoffer C Evans Margery L ML Chorell Erik E Sellstedt Magnus M Lindgren Anders E G AE Hufnagel David A DA Bhattacharya Moumita M Tessier Peter M PM Wittung-Stafshede Pernilla P Almqvist Fredrik F Chapman Matthew R MR
Chemistry & biology 20130912 10
Enteric bacteria assemble functional amyloid fibers, curli, on their surfaces that share structural and biochemical properties with disease-associated amyloids. Here, we test rationally designed 2-pyridone compounds for their ability to alter amyloid formation of the major curli subunit CsgA. We identified several compounds that discourage CsgA amyloid formation and several compounds that accelerate CsgA amyloid formation. The ability of inhibitor compounds to stop growing CsgA fibers was compar ...[more]