Ontology highlight
ABSTRACT:
SUBMITTER: Jain N
PROVIDER: S-EPMC5699053 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Jain Neha N Ådén Jörgen J Nagamatsu Kanna K Evans Margery L ML Li Xinyi X McMichael Brennan B Ivanova Magdalena I MI Almqvist Fredrik F Buxbaum Joel N JN Chapman Matthew R MR
Proceedings of the National Academy of Sciences of the United States of America 20171030 46
During biofilm formation, <i>Escherichia coli</i> and other Enterobacteriaceae produce an extracellular matrix consisting of curli amyloid fibers and cellulose. The precursor of curli fibers is the amyloidogenic protein CsgA. The human systemic amyloid precursor protein transthyretin (TTR) is known to inhibit amyloid-β (Aβ) aggregation in vitro and suppress the Alzheimer's-like phenotypes in a transgenic mouse model of Aβ deposition. We hypothesized that TTR might have broad antiamyloid activity ...[more]