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Scalable units for building cardiac tissue.

ABSTRACT: Scalable units for building cardiac tissue are fabricated from biodegradable elastomeric polymers by pairwise stacking of heart-cell scaffolds with sinusoidal internal pore architectures and dedicated perfusable microvessels with rapidly degrading porous interfaces in a parallel flow configuration. This platform supports viable heart cells in vitro and, if validated in vivo, may aid in the regenerative repair of vascularized tissues.

SUBMITTER: Ye X 

PROVIDER: S-EPMC4245075 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Scalable units for building cardiac tissue.

Ye Xiaofeng X   Lu Liang L   Kolewe Martin E ME   Hearon Keith K   Fischer Kristin M KM   Coppeta Jonathan J   Freed Lisa E LE  

Advanced materials (Deerfield Beach, Fla.) 20140919 42

Scalable units for building cardiac tissue are fabricated from biodegradable elastomeric polymers by pairwise stacking of heart-cell scaffolds with sinusoidal internal pore architectures and dedicated perfusable microvessels with rapidly degrading porous interfaces in a parallel flow configuration. This platform supports viable heart cells in vitro and, if validated in vivo, may aid in the regenerative repair of vascularized tissues. ...[more]

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