Ontology highlight
ABSTRACT:
SUBMITTER: Tran TA
PROVIDER: S-EPMC4245161 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
ACS chemical biology 20140916 11
Epigenetic regulation of gene expression is essential in many biological processes, and its deregulation contributes to pathology including tumor formation. We used an image-based cell assay that measures the induction of a silenced GFP-estrogen receptor reporter to identify novel classes of small molecules involved in the regulation of gene expression. Using this Locus Derepression assay, we queried 283,122 compounds by quantitative high-throughput screening evaluating compounds at multiple con ...[more]