Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Duenas V
PROVIDER: S-EPMC4245165 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Fernández-Dueñas Víctor V Gómez-Soler Maricel M López-Cano Marc M Taura Jaume J JJ Ledent Catherine C Watanabe Masahiko M Jacobson Kenneth A KA Vilardaga Jean-Pierre JP Ciruela Francisco F
ACS chemical biology 20141002 11
Caffeine, the most consumed psychoactive substance worldwide, may have beneficial effects on Parkinson's disease (PD) therapy. The mechanism by which caffeine contributes to its antiparkinsonian effects by acting as either an adenosine A2A receptor (A2AR) neutral antagonist or an inverse agonist is unresolved. Here we show that caffeine is an A2AR inverse agonist in cell-based functional studies and in experimental parkinsonism. Thus, we observed that caffeine triggers a distinct mode, opposite ...[more]