Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Duenas V
PROVIDER: S-EPMC4283650 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Fernández-Dueñas Víctor V Taura Jaume J JJ Cottet Martin M Gómez-Soler Maricel M López-Cano Marc M Ledent Catherine C Watanabe Masahiko M Trinquet Eric E Pin Jean-Philippe JP Luján Rafael R Durroux Thierry T Ciruela Francisco F
Disease models & mechanisms 20141114 1
Parkinson's disease (PD) is a dopaminergic-related pathology in which functioning of the basal ganglia is altered. It has been postulated that a direct receptor-receptor interaction - i.e. of dopamine D2 receptor (D2R) with adenosine A2A receptor (A2AR) (forming D2R-A2AR oligomers) - finely regulates this brain area. Accordingly, elucidating whether the pathology prompts changes to these complexes could provide valuable information for the design of new PD therapies. Here, we first resolved a lo ...[more]