Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi M
PROVIDER: S-EPMC4246057 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Takahashi Masamichi M Valdes Gilmer G Hiraoka Kei K Inagaki Akihito A Kamijima Shuichi S Micewicz Ewa E Gruber Harry E HE Robbins Joan M JM Jolly Douglas J DJ McBride William H WH Iwamoto Keisuke S KS Kasahara Noriyuki N
Cancer gene therapy 20141010 10
A tumor-selective non-lytic retroviral replicating vector (RRV), Toca 511, and an extended-release formulation of 5-fluorocytosine (5-FC), Toca FC, are currently being evaluated in clinical trials in patients with recurrent high-grade glioma (NCT01156584, NCT01470794 and NCT01985256). Tumor-selective propagation of this RRV enables highly efficient transduction of glioma cells with cytosine deaminase (CD), which serves as a prodrug activator for conversion of the anti-fungal prodrug 5-FC to the ...[more]