Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell LA
PROVIDER: S-EPMC6481342 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Mitchell Leah A LA Yagiz Kader K Hofacre Andrew A Viaud Sophie S Munday Anthony W AW Espinoza Fernando Lopez FL Mendoza Daniel D Rodriguez-Aguirre Maria E ME Bergqvist Simon S Haghighi Ali A Miner Marin V MV Accomando William P WP Burrascano Cynthia C Gammon Dawn D Gruber Harry E HE Jolly Douglas J DJ Lin Amy H AH
Oncotarget 20190319 23
Immune checkpoint inhibitors (CPIs) are associated with a number of immune-related adverse events and low response rates. We provide preclinical evidence for use of a retroviral replicating vector (RRV) selective to cancer cells, to deliver CPI agents that may circumvent such issues and increase efficacy. An RRV, RRV-scFv-PDL1, encoding a secreted single chain variable fragment targeting PD-L1 can effectively compete with PD-1 for PD-L1 occupancy. Cell binding assays showed trans-binding activit ...[more]