Ontology highlight
ABSTRACT:
SUBMITTER: Ksander BR
PROVIDER: S-EPMC4246512 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Ksander Bruce R BR Kolovou Paraskevi E PE Wilson Brian J BJ Saab Karim R KR Guo Qin Q Ma Jie J McGuire Sean P SP Gregory Meredith S MS Vincent William J B WJ Perez Victor L VL Cruz-Guilloty Fernando F Kao Winston W Y WW Call Mindy K MK Tucker Budd A BA Zhan Qian Q Murphy George F GF Lathrop Kira L KL Alt Clemens C Mortensen Luke J LJ Lin Charles P CP Zieske James D JD Frank Markus H MH Frank Natasha Y NY
Nature 20140702 7509
Corneal epithelial homeostasis and regeneration are sustained by limbal stem cells (LSCs), and LSC deficiency is a major cause of blindness worldwide. Transplantation is often the only therapeutic option available to patients with LSC deficiency. However, while transplant success depends foremost on LSC frequency within grafts, a gene allowing for prospective LSC enrichment has not been identified so far. Here we show that ATP-binding cassette, sub-family B, member 5 (ABCB5) marks LSCs and is re ...[more]