Proteomics

Dataset Information

0

ABCB5+ limbal epithelial stem cells inhibit developmental, but promote inflammatory (lymph)angiogenesis while preventing corneal inflammation


ABSTRACT: ABCB5 is marker for Limbal epithilal stem cells. A comparison between ABCB5+ versus ABCB5- cultured human limbal epithelial cells was carried out to evaluate the properties of the limbal stem cell ABCB5+ with a special focus on their role in inflammation and angiogenesis.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Corneal Epithelium

SUBMITTER: Prerana Wagle  

LAB HEAD: Maria Notara

PROVIDER: PXD041004 | Pride | 2023-10-24

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
2629_PRIDE.zip Other
E2_ColID_257_2629_01.raw Raw
E2_ColID_257_2629_02.raw Raw
E2_ColID_257_2629_03.raw Raw
E2_ColID_257_2629_04.raw Raw
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Publications

ABCB5+ Limbal Epithelial Stem Cells Inhibit Developmental but Promote Inflammatory (Lymph) Angiogenesis While Preventing Corneal Inflammation.

Meshko Berbang B   Volatier Thomas L A TLA   Hadrian Karina K   Deng Shuya S   Hou Yanhong Y   Kluth Mark Andreas MA   Ganss Christoph C   Frank Markus H MH   Frank Natasha Y NY   Ksander Bruce B   Cursiefen Claus C   Notara Maria M  

Cells 20230627 13


The limbus, the vascularized junction between the cornea and conjunctiva, is thought to function as a barrier against corneal neovascularization. However, the exact mechanisms regulating this remain unknown. In this study, the limbal epithelial stem cell (LESC) marker ABCB5 was used to investigate the role of LESCs in corneal neovascularization. In an ABCB5KO model, a mild but significant increase of limbal lymphatic and blood vascular network complexity was observed in developing mice (4 weeks)  ...[more]

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