Ontology highlight
ABSTRACT:
SUBMITTER: Vatner RE
PROVIDER: S-EPMC4246656 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Frontiers in oncology 20141128
The immune system has the ability to recognize and specifically reject tumors, and tumors only become clinically apparent once they have evaded immune destruction by creating an immunosuppressive tumor microenvironment. Radiotherapy (RT) can cause immunogenic tumor cell death resulting in cross-priming of tumor-specific T-cells, acting as an in situ tumor vaccine; however, RT alone rarely induces effective anti-tumor immunity resulting in systemic tumor rejection. Immunotherapy can complement RT ...[more]