Ontology highlight
ABSTRACT:
SUBMITTER: Asna N
PROVIDER: S-EPMC6209565 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Asna N N Livoff A A Batash R R Debbi R R Schaffer P P Rivkind T T Schaffer M M
Current oncology (Toronto, Ont.) 20181031 5
<h4>Background</h4>Radiation therapy (rt) is a longstanding treatment modality for cancer. In addition, immune checkpoint blockade has been a significant development in the field of immunotherapy, modifying key immunosuppressive pathways of cancer cells.<h4>Methods</h4>The aim of the present work was to review current concepts of rt and immunotherapy synergism, the abscopal effect, and the molecular effects of rt in the tumour microenvironment, its influence on immune stimulation, and potential ...[more]