Ontology highlight
ABSTRACT:
SUBMITTER: Lam AM
PROVIDER: S-EPMC4249362 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Lam Angela M AM Edwards Thomas E TE Mosley Ralph T RT Murakami Eisuke E Bansal Shalini S Lugo Christopher C Bao Haiying H Otto Michael J MJ Sofia Michael J MJ Furman Phillip A PA
Antimicrobial agents and chemotherapy 20140902 11
Resistance to the 2'-F-2'-C-methylguanosine monophosphate nucleotide hepatitis C virus (HCV) inhibitors PSI-352938 and PSI-353661 was associated with a combination of amino acid changes (changes of S to G at position 15 [S15G], C223H, and V321I) within the genotype 2a nonstructural protein 5B (NS5B), an RNA-dependent RNA polymerase. To understand the role of these residues in viral replication, we examined the effects of single and multiple point mutations on replication fitness and inhibition b ...[more]