Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination.

ABSTRACT: Rubella virus causes a relatively benign disease in most cases, although infection during pregnancy can result in serious birth defects. An effective vaccine has been available since the early 1970s and outbreaks typically do not occur among highly vaccinated (≥2 doses) populations. Nevertheless, considerable inter-individual variation in immune response to rubella immunization does exist, with single-dose seroconversion rates ~95 %. Understanding the mechanisms behind this variability may provide important insights into rubella immunity. In the current study, we examined associations between single nucleotide polymorphisms (SNPs) in selected cytokine, cytokine receptor, and innate/antiviral genes and immune responses following rubella vaccination in order to understand genetic influences

SUBMITTER: Kennedy RB 

PROVIDER: S-EPMC4249927 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature