Single nucleotide polymorphisms/haplotypes associated with multiple rubella-specific immune response outcomes post-MMR immunization in healthy children.
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ABSTRACT:
SUBMITTER: Ovsyannikova IG
PROVIDER: S-EPMC4587390 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Single nucleotide polymorphisms/haplotypes associated with multiple rubella-specific immune response outcomes post-MMR immunization in healthy children.
Ovsyannikova Inna G IG Salk Hannah M HM Larrabee Beth R BR Pankratz V Shane VS Poland Gregory A GA
Immunogenetics 20150902 10
The observed heterogeneity in rubella-specific immune response phenotypes post-MMR vaccination is thought to be explained, in part, by inter-individual genetic variation. In this study, single nucleotide polymorphisms (SNPs) and multiple haplotypes in several candidate genes were analyzed for associations with more than one rubella-specific immune response outcome, including secreted IFN-γ, secreted IL-6, and neutralizing antibody titers. Overall, we identified 23 SNPs in 10 different genes that ...[more]
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