Ontology highlight
ABSTRACT:
SUBMITTER: Arnold CD
PROVIDER: S-EPMC4250274 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Arnold Cosmas D CD Gerlach Daniel D Spies Daniel D Matts Jessica A JA Sytnikova Yuliya A YA Pagani Michaela M Lau Nelson C NC Stark Alexander A
Nature genetics 20140608 7
Phenotypic differences between closely related species are thought to arise primarily from changes in gene expression due to mutations in cis-regulatory sequences (enhancers). However, it has remained unclear how frequently mutations alter enhancer activity or create functional enhancers de novo. Here we use STARR-seq, a recently developed quantitative enhancer assay, to determine genome-wide enhancer activity profiles for five Drosophila species in the constant trans-regulatory environment of D ...[more]