Dataset Information

Vascular endothelial growth factor (VEGF-634G/C) polymorphism and retinopathy of prematurity: a meta-analysis.

ABSTRACT:

Purpose

Vascular endothelial growth factor polymorphism (VEGF-634G/C, rs 2010963) has been considered a risk factor for the development of retinopathy of prematurity (ROP). However, the results remain controversial. Therefore, the aim of the present meta-analysis was to determine the association between VEGF-634G/C polymorphism and ROP risk.

Methods

Published literature from PubMed and other databases were retrieved. All studies evaluating the association between VEGF-634G/C polymorphism and ROP risk were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random or fixed effects model. A total of six case-control studies including 355 cases and 471 controls were included.

Results

By pooling all the studies, we found that VEGF-634G/C polymorphism was not associated with ROP risk at co-dominant and allele levels and no association was also found in dominant and recessive models. While stratifying on ethnicity level no association was observed in Caucasian and Asian population.

Discussion

This meta-analysis suggests that VEGF-634G/C polymorphism may not be associated with ROP risk, the association between single VEGF-634G/C polymorphism and ROP risk awaits further investigation.

SUBMITTER: Malik MA

PROVIDER: S-EPMC4250490 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Publications

Vascular endothelial growth factor (VEGF-634G/C) polymorphism and retinopathy of prematurity: a meta-analysis.

Malik Manzoor Ahmad MA Shukla Swati S Azad Shorya Vardhan SV Kaur Jasbir J

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society 20140724 4

<h4>Purpose</h4>Vascular endothelial growth factor polymorphism (VEGF-634G/C, rs 2010963) has been considered a risk factor for the development of retinopathy of prematurity (ROP). However, the results remain controversial. Therefore, the aim of the present meta-analysis was to determine the association between VEGF-634G/C polymorphism and ROP risk.<h4>Methods</h4>Published literature from PubMed and other databases were retrieved. All studies evaluating the association between VEGF-634G/C polym ...[more]

PMID: 25473347

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Project description:OBJECTIVE:To investigate the relationship between vascular endothelial growth factor (VEGF) gene polymorphisms and Retinopathy of prematurity (ROP) development in preterm infants of China Han ethnic population. METHODS:VEGF gene promoter polymorphisms (-165C/T and -141A/C) were studied in 54 neonates with ROP but not requiring treatment (regressive ROP group), 48 neonates with ROP that requires cryotherapy/photocoagulation (severe ROP group), and in a control group of 62 preterm infants without ROP. Genotyping for VEGF gene promoter was performed by polymerase chain reaction (PCR) and gene sequencing. RESULTS:In this study, -165C/T genotype was found to be associated with severe ROP (P=0.012<0.05), but not with regressive ROP. For the dominant genetic model, subjects carrying the -165T allele had a decreased risk of ROP compared to those non-carrying the -165C allele in both regressive ROP regressive group and severe ROP group, and especially in severe ROP group (in regressive ROP group: OR=2.069, 95% CI=0.986-4.340; in severe ROP group: OR=3.677, 95% CI=1.339-10.099). For the allelic model, comparing the A allele to the C allele, the -165C/T site also showed a decreased risk of ROP in both regressive ROP group and severe ROP group (in regressive ROP group: OR=2.395, 95% CI=1.112-5.157; in severe ROP group: OR=4.258, 95% CI=1.518-11.945). In -141A/C genotypes and alleles were found not to be associated with severe ROP or regressive ROP. Linkage disequilibrium analysis revealed -165C/T and -141A/C were a strong linkage disequilibrium, and haplotype analysis revealed that T-165C-141 haplotype was associated with resistance to severe ROP but C-165A-141 haplotype was associated with risk to severe ROP. No statistically significant differences were observed in regressive ROP group. CONCLUSION:VEGF -165C/T SNP is associated with ROP especial in severe ROP. VEGF -141A/C SNP is not associated with ROP. T-165C-141 and C-165A-141 haplotypes may have a role in severe ROP.

Dataset Information

Vascular endothelial growth factor (VEGF-634G/C) polymorphism and retinopathy of prematurity: a meta-analysis.

Purpose

Methods

Results

Discussion

Publications

Vascular endothelial growth factor (VEGF-634G/C) polymorphism and retinopathy of prematurity: a meta-analysis.

Similar Datasets

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