Ontology highlight
ABSTRACT:
SUBMITTER: Nelson C
PROVIDER: S-EPMC4252298 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Nelson Charles C Ambros Victor V Baehrecke Eric H EH
Molecular cell 20141009 3
Macroautophagy (autophagy) is a lysosome-dependent degradation process that has been implicated in age-associated diseases. Autophagy is involved in both cell survival and cell death, but little is known about the mechanisms that distinguish its use during these distinct cell fates. Here, we identify the microRNA miR-14 as being both necessary and sufficient for autophagy during developmentally regulated cell death in Drosophila. Loss of miR-14 prevented induction of autophagy during salivary gl ...[more]