Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer.
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ABSTRACT:
SUBMITTER: Scheiermann J
PROVIDER: S-EPMC4252359 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer.
Scheiermann Julia J Klinman Dennis M DM
Vaccine 20140624 48
Synthetic oligonucleotides (ODN) that express unmethylated "CpG motifs" trigger cells that express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells. CpG ODN induce an innate immune response characterized by the production of Th1 and pro-inflammatory cytokines. Their utility as vaccine adjuvants was evaluated in a number of clinical trials. Results indicate that CpG ODN improve antigen presentation and the generation of vaccine-specific cellular and humoral r ...[more]
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