Ontology highlight
ABSTRACT:
SUBMITTER: Feng X
PROVIDER: S-EPMC4252625 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Chemistry & biology 20141009 11
YisP is involved in biofilm formation in Bacillus subtilis and has been predicted to produce C30 isoprenoids. We determined the structure of YisP and observed that it adopts the same fold as squalene and dehydrosqualene synthases. However, the first aspartate-rich motif found in essentially all isoprenoid synthases is aspartate poor in YisP and cannot catalyze head-to-head condensation reactions. We find that YisP acts as a phosphatase, catalyzing formation of farnesol from farnesyl diphosphate, ...[more]