Structural changes of TasA in biofilm formation of Bacillus subtilis.
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ABSTRACT:
SUBMITTER: Diehl A
PROVIDER: S-EPMC5879678 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Structural changes of TasA in biofilm formation of <i>Bacillus subtilis</i>.
Diehl Anne A Roske Yvette Y Ball Linda L Chowdhury Anup A Hiller Matthias M Molière Noel N Kramer Regina R Stöppler Daniel D Worth Catherine L CL Schlegel Brigitte B Leidert Martina M Cremer Nils N Erdmann Natalja N Lopez Daniel D Stephanowitz Heike H Krause Eberhard E van Rossum Barth-Jan BJ Schmieder Peter P Heinemann Udo U Turgay Kürşad K Akbey Ümit Ü Oschkinat Hartmut H
Proceedings of the National Academy of Sciences of the United States of America 20180312 13
Microorganisms form surface-attached communities, termed biofilms, which can serve as protection against host immune reactions or antibiotics. <i>Bacillus subtilis</i> biofilms contain TasA as major proteinaceous component in addition to exopolysaccharides. In stark contrast to the initially unfolded biofilm proteins of other bacteria, TasA is a soluble, stably folded monomer, whose structure we have determined by X-ray crystallography. Subsequently, we characterized in vitro different oligomeri ...[more]
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